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SLAS2019 Short Courses

Assay Guidance Workshop for High-Throughput Screening and Lead Discovery

Sponsored by Cisbio 

Saturday, February 2, 2019 — 8:00 a.m. - 5:00 p.m. (local time)

Registration

This workshop is available to SLAS2019 registrants only and requires an additional registration fee of $399.00. Click here to register now.*

*Attendees are also invited to Assays, Applications and Appetizers from 5 - 7 p.m.

Join Cisbio for a reception immediately following the workshop for complimentary appetizers and HTRF signature cocktails, while enjoying live music and the company of other industry professionals. Space is limited. Please RSVP to secure your spot. 

Summary

This full-day workshop will cover a broad range of critical concepts underlying assay development for high throughput screening (HTS) and lead discovery projects. Many of the methodologies successfully implemented in such projects have been "tribal knowledge" within the pharmaceutical industry and not readily found in a classroom or the literature. This "tribal knowledge" has been developed for decades into detailed chapters within the AGM to facilitate reproducible assays that can identify the most promising compounds for the development of molecular probes or clinical candidates for drug discovery and development. An increasing number of researchers are actively developing well-validated assays for drug discovery that include phenotypic and biochemical assays for lead optimization. This workshop is designed to disseminate critical information about the implementation of robust assay methods and intended to benefit the entire drug discovery community. Many of the workshop instructors have 20-30 years of experience in the field of drug discovery.

Who Should Attend?

The target audience is individuals involved in bioassay development for drug discovery and development. The AGM and this workshop will be a valuable resource for academic, industrial and government laboratory scientists who are planning or beginning to develop test methods for high or low throughput screening that are amenable to automation using appropriate statistical and operational concepts. The workshop will also be useful for early career researchers and experienced investigators who wish to learn about the latest assay concepts for HTS and lead optimization

Benefits

The workshop will provide participants with a broad, practical perspective on assay development so that they can (1) improve research projects involving drug discovery, and know where to find further information (2) identify reagents, methods and instrumentation that are well suited to robust assays (3) be able to develop robust assays and counter assays for new targets. Additionally, participants will have the opportunity to seek practical advice about individual research challenges.

Workshop Objectives

  1. Overview of the Assay Guidance Manual eBook as an important resource for detailed information about robust assay methods and best practices in quantitative biology.
  2. Practical approaches for developing robust assays for biochemical, cell-based, and high content screening as well as the selection and development of optimal assay reagents.
  3. Overview of sources of assay artifacts and strategies to identify artifacts through the development and implementation of counter assays.
  4. Discussion of important statistical and data analysis concepts with an emphasis on using these concepts to collect the best possible data and make go/no-go decisions based on experimental results.
  5. Open discussions to share experiences and seek practical advice about individual research concerns.

Workshop Agenda

8:00 a.m. – 8:20 a.m. Robust or Go Bust: An Introduction to the Assay Guidance Manual
G. Sitta Sittampalam, Ph.D., NCATS/NIH
8:20 a.m. – 9:05 a.m.

Key Concepts for Robust Biochemical & Cell-Based Assays
Timothy L. Foley, Ph.D., Pfizer Inc.

9:10 a.m. – 9:55 a.m. Treating Cells as Reagents to Design Reproducible Screening Assays
Terry Riss, Ph.D., Promega Corporation
10:00 a.m. – 10:30 a.m. Beverage Break
10:30 a.m. – 11:15 a.m. Assay Interpretation: Studies in Mechanisms and Methods in Assay Interferences
Douglas Auld, Ph.D., Novartis Institutes for BioMedical Research
11:15 a.m. – 12:00 p.m. Biophysical Approaches to Small Molecule Discovery and Validation
Michelle Arkin, Ph.D., University of California, San Francisco
12:00 p.m. – 1:00 p.m. Lunch
1:00 p.m. – 1:45 p.m. In Vitro Toxicological Testing using a qHTS Platform
Menghang Xia, Ph.D., NCATS/NIH
1:45 p.m. – 2:30 p.m. In Vitro Assessments of ADME Properties of Lead Compounds
Xin Xu, Ph.D., NCATS/NIH
2:30 p.m. – 3:00 p.m. Beverage Break
3:00 p.m. – 3:45 p.m. Basic Assay Statistics, Data Analysis and Rules of Thumb
Thomas D.Y. Chung, Ph.D., Mayo Clinic
3:50 p.m. – 4:35 p.m. System suitability of in vitro screening assays in drug discovery
V. Devanarayan, Ph.D., Charles River
4:40 p.m. – 5:00 p.m. Open Discussion

Our Sponsors

Premier Sponsor:
Hamilton

  • Diamond Sponsor

    Artel
  • Diamond Sponsor

    BMG Labtech
  • Diamond Sponsor

    Corning
  • Diamond Sponsor

    Scinomix
  • Diamond Sponsor

    Thermo Fisher Scientific
  • Diamond Sponsor

    Waters
  • Platinum Sponsor

    Beckman Coulter
  • Platinum Sponsor

    Hamamatsu
  • Platinum Sponsor

    Miltenyi Biotec
  • Platinum Sponsor

    Molecular Devices
  • Platinum Sponsor

    Tecan
  • Gold Sponsor

    Agilent
  • Gold Sponsor

    Biotek
  • Gold Sponsor

    Eppendorf
  • Gold Sponsor

    Gilson
  • Gold Sponsor

    HighRes Biosolutions
  • Gold Sponsor

    Labcyte
  • Gold Sponsor

    StemoniX
  • Silver Sponsor

    Analytik Jena
  • Silver Sponsor

    BioNex Solutions
  • Silver Sponsor

    Cisbio
  • Silver Sponsor

    Greiner Bio-One
  • Silver Sponsor

    NanoTemper
  • Silver Sponsor

    Sirius Automation Group
  • Silver Sponsor

    Titian
  • Media Partner

    Biocompare
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    C&EN
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    Cell Press
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    CLP
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    DDN News
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    DDW
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    DTR
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    GEN News
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    Labcompare
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    LabManager
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    Science AAAS
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    Select Science
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    Technology Networks
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    The Analytical Scientist
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    The Scientist
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    The Translational Scientist