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SLAS2019 Short Courses

An Introduction to Mass Spectrometry and its Applications within Drug Discovery

This short course will provide an introduction to mass spectrometry and the range of potential applications within drug discovery. We will cover the basic principles of mass spectrometry including the differences between the array of ionization modalities and detectors available today. While mass spectrometry has contributed significantly to drug discovery, recent advances are enabling high throughput screening applications.

Who Should Attend:

  • Lab scientists with an interest in understanding the fundamentals of mass spectrometry
  • Lab managers interested in understanding how mass spectrometry can impact drug discovery
  • Budget holders who are considering investing in mass spectrometry technology
  • Assay development scientists and HTS screeners who want to understand how mass spectrometry can impact their research

How You Will Benefit From This Course:

  • Get a better understanding of the principles of mass spectrometry
  • Gain an understanding of the diversity of instruments and ionization techiques
  • Understanding of where mass spectrometry can be applied with impact in drug discovery
  • Learn about recent developments in mass spectrometry

Course Topics:

  • Basic principles of mass spectrometry
  • Overview of ionization modalities and mass detectors
  • Introduction to separation techniques and matrix effects
  • Electrospray platforms for HTS applications
  • MALDI applications in drug discovery
  • Overview of MS imaging
  • Recent advances in MS technology and impact in drug discovery

Instructors:

Jonathan Wingfield

Jonathan Wingfield
AstraZeneca, Discovery Sciences

Nearly 20 years experience of assay development and automation of high throughput screening for drug discovery within pharma. Joined AstraZeneca (AZ) in 2000 to deliver technology solutions to support pre-clinical screening within the Oncology disease area. Established a centralized biochemical screening group which received the 2008 Microsoft Innovation in Pharma Award. Involved in the deployment of acoustic technology within AZ which ultimately lead to a project to investigate the integration of an acoustic source as a loading system for mass spectrometry. This project received the Innovation Award at SLAS 2015.

Ian Sinclair

Ian Sinclair
AstraZeneca, Discovery Sciences

With over 20 years of experience in mass spectrometry, gained initially with a major manufacturer building and supporting field instrumentation. Joined Astrazeneca in 2000 to support their suite of instruments and develop high throughput, open access solutions for chemistry and DMPK. More recently i have been invloved in applying these principles to generating detection systems for cellular and biochemical screening application and it is this work that has led to the development of the acoustic interface for a mass spectrometer.


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